Permanent Central Synaptic Disconnection of Proprioceptors 1 after Nerve Injury and Regeneration : I . Loss
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چکیده
Permanent Central Synaptic Disconnection of Proprioceptors 1 after Nerve Injury and Regeneration: I. Loss of VGLUT1/IA 2 synapses on motoneurons 3 4 5 6 Authors: Francisco J. Alvarez*, Haley E. Titus-Mitchell, Katie L. Bullinger, Michal 7 Kraszpulski, Paul Nardelli, Timothy C. Cope 8 9 10 Institutional affiliations: 11 Department of Neuroscience, Cell Biology and Physiology, Boonshoft School of 12 Medicine, Wright State University, Dayton, Ohio 45435 13 14 * New address: Department of Physiology, Emory University, Atlanta, Georgia, 30322 15 16 17 Running head: Permanent IA-motoneuron disconnection induced by peripheral nerve 18 injury. 19 20 21 Corresponding Author: 22 Francisco J. Alvarez, 23 Department of Physiology, 24 Emory University School of Medicine, 25 Whitehead Research Building, Room 642, 26 615 Michael Street, 27 Atlanta, GA, 30322. 28 Phone 404-727-5139; 29 Email: [email protected] 30 31 32 Articles in PresS. J Neurophysiol (August 10, 2011). doi:10.1152/jn.01095.2010
منابع مشابه
Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons.
Motor and sensory proprioceptive axons reinnervate muscles after peripheral nerve transections followed by microsurgical reattachment; nevertheless, motor coordination remains abnormal and stretch reflexes absent. We analyzed the possibility that permanent losses of central IA afferent synapses, as a consequence of peripheral nerve injury, are responsible for this deficit. VGLUT1 was used as a ...
متن کاملPermanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. II. Loss of functional connectivity with motoneurons.
Regeneration of a cut muscle nerve fails to restore the stretch reflex, and the companion paper to this article [Alvarez FJ, Titus-Mitchell HE, Bullinger KL, Kraszpulski M, Nardelli P, Cope TC. J Neurophysiol (August 10, 2011). doi:10.1152/jn.01095.2010] suggests an important central contribution from substantial and persistent disassembly of synapses between regenerated primary afferents and m...
متن کاملPermanent Central Synaptic Disconnection of Proprioceptors after Nerve Injury
Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 8 45435. 9 Department of Physiology, Emory University, Atlanta, GA, 30322 10 11 Corresponding author: 12 Timothy C. Cope 13 Department of Neuroscience, Cell Biology & Physiology 14 Wright State University School of Medicine 15 3640 Colonel Glenn Hwy 16 Dayton OH 45435 17 18 [email protected] 19 2...
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